[HTML][HTML] A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

MA O'Connor, DW Hawman, K Meade-White… - Plos …, 2023 - journals.plos.org
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines.
Although several vaccines have received emergency approval through various public health …

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

JH Erasmus, AP Khandhar, MA O'Connor… - Science translational …, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

JH Erasmus, AP Khandhar, AC Walls, EA Hemann… - bioRxiv, 2020 - biorxiv.org
The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a
dramatic and deleterious impact on health services and the global economy. Grim public …

[HTML][HTML] Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection

AR Rappaport, SJ Hong, CD Scallan, L Gitlin… - Nature …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to spread globally,
highlighting the urgent need for safe and effective vaccines that could be rapidly mobilized …

[HTML][HTML] A simplified SARS-CoV-2 mouse model demonstrates protection by an oral replicon-based mRNA vaccine

V Jawalagatti, P Kirthika, C Hewawaduge… - Frontiers in …, 2022 - frontiersin.org
A mouse model of SARS-CoV-2 that can be developed in any molecular biology lab with
standard facilities will be valuable in evaluating drugs and vaccines. Here we present a …

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

DW Hawman, K Meade-White, J Archer, SS Leventhal… - Elife, 2022 - elifesciences.org
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with
resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants …

[HTML][HTML] Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters

JGB Diego, G Singh, S Jangra, K Handrejk… - PLoS …, 2024 - journals.plos.org
Hybrid immunity (vaccination+ natural infection) to SARS-CoV-2 provides superior
protection to re-infection. We performed immune profiling studies during breakthrough …

[HTML][HTML] DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice

I Szurgot, L Hanke, DJ Sheward, LP Vidakovics… - Scientific Reports, 2021 - nature.com
The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made
the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a …

[PDF][PDF] CV2CoV, an enhanced mRNA-based SARS-CoV-2 vaccine candidate, supports higher protein expression and improved immunogenicity in rats

N Roth, J Schön, D Hoffmann, M Thran, A Thess… - BioRxiv, 2021 - scholar.archive.org
More than a year after emergence of the SARS-CoV-2 pandemic, multiple first-generation
vaccines are approved and available for vaccination. Still, many challenges remain. The …

[HTML][HTML] Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models

F Lelis, LA Byk, S Pustylnikov, V Nguyen, B Nguyen… - Scientific Reports, 2023 - nature.com
Several COVID-19 vaccines, some more efficacious than others, are now available and
deployed, including multiple mRNA-and viral vector-based vaccines. With the focus on …