Concise review: aggressive colorectal cancer: role of epithelial cell adhesion molecule in cancer stem cells and epithelial-to-mesenchymal transition

M Boesch, G Spizzo, A Seeber - Stem cells translational …, 2018 - academic.oup.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of
various attempts to ameliorate outcome by escalating treatment, significant improvement is …

Is Ep-CAM expression a diagnostic and prognostic biomarker for colorectal cancer? A systematic meta-analysis

S Han, S Zong, Q Shi, H Li, S Liu, W Yang, W Li… - …, 2017 - thelancet.com
Background Cancer stem cell (CSC) epithelial cell adhesion molecule (Ep-CAM) is
frequently expressed in colorectal cancer (CRC). However, the clinical significance of Ep …

Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis

CC Lee, CJ Yu, SS Panda, KC Chen, KH Liang… - Journal of Translational …, 2023 - Springer
Background Epithelial cell adhesion molecule (EpCAM) is known to highly expression and
promotes cancer progression in many cancer types, including colorectal cancer. While …

[HTML][HTML] An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

MY Liao, JK Lai, MYP Kuo, RM Lu, CW Lin, PC Cheng… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Epithelial cell adhesion molecule (EpCAM) is known to be overexpressed in epithelial
cancers associated with enhanced malignant potential, particularly colorectal carcinoma …

The emerging role of EpCAM in cancer and stem cell signaling

M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface …

Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells

KH Liang, HC Tso, SH Hung, II Kuan, JK Lai, FY Ke… - Cancer letters, 2018 - Elsevier
Epithelial cell adhesion molecule (EpCAM) is highly expressed in colon cancers, but its role
in cancer progression remains to be elucidated. In this work, we found that the extracellular …

Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer

E Kalantari, T Taheri, S Fata, M Abolhasani… - World Journal of …, 2022 - Springer
Background The crucial oncogenic role of cancer stem cells (CSCs) in tumor maintenance,
progression, drug resistance, and relapse has been clarified in different cancers, particularly …

When wishful thinking leads to a misty-eyed appraisal: the story of the adjuvant colon cancer trials with edrecolomab

HJ Schmoll, D Arnold - Journal of Clinical Oncology, 2009 - ascopubs.org
Colorectal cancer is the most frequently occurring cancer in the Western world, with a
worldwide incidence of about 1 million, and with 70% to 80% of patients presenting initially …

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

EpCAM: a new therapeutic target for an old cancer antigen

A Armstrong, SL Eck - Cancer biology & therapy, 2003 - Taylor & Francis
The use of monoclonal antibodies as adjuvants to cancer chemotherapy has drawn
considerable interest in recent years, due to the success of several novel agents against a …