Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

G Lanzoni, E Linetsky, D Correa… - Stem cells …, 2021 - academic.oup.com
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality.
Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory …

Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: a randomized controlled trial

IH Dilogo, D Aditianingsih, A Sugiarto… - Stem cells …, 2021 - academic.oup.com
One of the main causes of acute respiratory distress syndrome in coronavirus disease 2019
(COVID-19) is cytokine storm, although the exact cause is still unknown. Umbilical cord …

Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial

F Meng, R Xu, S Wang, Z Xu, C Zhang, Y Li… - Signal transduction and …, 2020 - nature.com
No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-
directed therapies targeting the underlying aberrant immune responses leading to …

Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trial

N Kaffash Farkhad, A Sedaghat, H Reihani… - Stem Cell Research & …, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is the devastating complication of
the new COVID-19 pandemic, directly correlated with releasing large amounts of …

Administration of umbilical cord mesenchymal stem cells in patients with severe COVID-19 pneumonia

Z Guo, Y Chen, X Luo, X He, Y Zhang, J Wang - Critical care, 2020 - Springer
There are no specific drug therapies or vaccines for the pandemic of coronavirus disease
2019 (COVID-19), which is associated with substantial mortality. Attenuating or reversing the …

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

SMR Hashemian, R Aliannejad, M Zarrabi… - Stem cell research & …, 2021 - Springer
Background Acute respiratory distress syndrome (ARDS) is a fatal complication of
coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human …

Safety and feasibility of umbilical cord mesenchymal stem cells in patients with COVID‐19 pneumonia: A pilot study

Y Feng, J Huang, J Wu, Y Xu, B Chen, L Jiang… - Cell …, 2020 - Wiley Online Library
Objectives We aim to explore the safety and feasibility of umbilical cord mesenchymal stem
cells (UC‐MSCs) transplantation in patients with severe and critically severe coronavirus …

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells

L Shu, C Niu, R Li, T Huang, Y Wang, M Huang… - Stem cell research & …, 2020 - Springer
Background COVID-19 is a highly infectious respiratory disease. No therapeutics have yet
been proven effective for treating severe COVID-19. Objectives To determine whether …

Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase …

L Shi, H Huang, X Lu, X Yan, X Jiang, R Xu… - Signal transduction and …, 2021 - nature.com
Abstract Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We
performed a phase 2 trial to assess the efficacy and safety of human umbilical cord …

Human mesenchymal stem cells treatment for severe COVID-19: 1-year follow-up results of a randomized, double-blind, placebo-controlled trial

L Shi, X Yuan, W Yao, S Wang, C Zhang, B Zhang… - …, 2022 - thelancet.com
Background The long-term consequences of human umbilical cord-derived mesenchymal
stem cell (UC-MSC) treatment for COVID-19 patients are yet to be reported. This study …