In studies of immune aging, naive T cells frequently take center stage. Describing the
complexity of the human naive T cell repertoire remains a daunting task; however, emerging …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

The immune system exhibits profound age-related changes, collectively termed
immunosenescence. The most visible of these is the decline in protective immunity, which …

The T cell system is a complex and highly dynamic system that is amazingly robust over
many decades of human life. Its functional competence is determined not only by its size but …

Naïve and memory CD4 and CD8 T cells constitute a highly dynamic system with constant
homeostatic and antigen-driven proliferation, influx, and loss of T cells. Thymic activity …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-
cellular milieu and together these processes ensure that a population of naive CD4 T cells …