Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

α-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and
fibrillation of which are implicated as critical factors in several neurodegenerative diseases …

α-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind
to lipid membranes and acquire a partial α-helical conformation. Under certain pathogenic …

Aggregation of α-synuclein is tightly associated with many neurodegenerative diseases,
such as Parkinson's disease, dementia with Lewy body, Lewy body variant of Alzheimer's …

Abstract α-Synuclein is a conserved, abundantly expressed protein that is partially localized
in pre-synaptic terminals in the central nervous system. The precise biological function (s) …

Parkinson's disease is the second most common neurodegenerative disease, and results
from loss of dopaminergic neurons in the substantia nigra. The aggregation and fibrillation of …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

Protein misfolding and aggregation is a ubiquitous phenomenon associated with a wide
range of diseases. The synuclein family comprises three small naturally unfolded proteins …

Biochemcal and genetic evidence point towards α-synuclein aggregation as having a pivotal
role in the onset and progression of several neurodegenerative disorders, including …

Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of α-synuclein are
hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy …