Q-Griffithsin interactions and utility for the prevention and treatment of Mucosal infections.
H Nabeta - 2021 - ir.library.louisville.edu
Griffithsin (GRFT) is a carbohydrate binding agent (lectin) that was originally identified in the
red alga Griffithsia sp. Q-Griffithsin (Q-GRFT) is an oxidation stable analog of GRFT. GRFT …
red alga Griffithsia sp. Q-Griffithsin (Q-GRFT) is an oxidation stable analog of GRFT. GRFT …
Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models
C Barton, JC Kouokam, AB Lasnik… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-
linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2 …
linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2 …
Evaluation of the safety and pharmacokinetic profile of the broad spectrum antiviral lectin Griffithsin.
CL Barton - 2014 - ir.library.louisville.edu
Carbohydrate binding agents that target viral envelope glycans are being studied for their
potential use as microbicides and antiviral therapeutics. Griffithsin is a lectin originally …
potential use as microbicides and antiviral therapeutics. Griffithsin is a lectin originally …
[HTML][HTML] Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis
HW Nabeta, AB Lasnik, JL Fuqua, L Wang… - Frontiers in Cellular …, 2022 - frontiersin.org
Resistance to antifungal agents in vulvovaginal candidiasis has resulted in increasing
morbidity among women globally. It is therefore crucial that new antimycotic agents are …
morbidity among women globally. It is therefore crucial that new antimycotic agents are …
Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus
K Levendosky, O Mizenina, E Martinelli… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Extensive preclinical evaluation of griffithsin (GRFT) has identified this lectin to be a
promising broad-spectrum microbicide. We set out to explore the antiviral properties of a …
promising broad-spectrum microbicide. We set out to explore the antiviral properties of a …
[HTML][HTML] Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate
JC Kouokam, D Huskens, D Schols, A Johannemann… - Plos one, 2011 - journals.plos.org
Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have
potent in vitro activity against viruses that display dense clusters of oligomannose N-linked …
potent in vitro activity against viruses that display dense clusters of oligomannose N-linked …
[HTML][HTML] Griffithsin: an antiviral lectin with outstanding therapeutic potential
S Lusvarghi, CA Bewley - Viruses, 2016 - mdpi.com
Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors
discovered to date. It is currently being developed as a microbicide with broad-spectrum …
discovered to date. It is currently being developed as a microbicide with broad-spectrum …
[HTML][HTML] Studies in a murine model confirm the safety of griffithsin and advocate its further development as a microbicide targeting HIV-1 and other enveloped viruses
JC Kouokam, AB Lasnik, KE Palmer - Viruses, 2016 - mdpi.com
Griffithsin (GRFT), a lectin from Griffithsia species, inhibits human immunodeficiency virus-1
(HIV-1) replication at sub-nanomolar concentrations, with limited cellular toxicity. However …
(HIV-1) replication at sub-nanomolar concentrations, with limited cellular toxicity. However …
[HTML][HTML] Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.
T Mori, BR O'Keefe, RC Sowder, S Bringans… - Journal of Biological …, 2005 - ASBMB
Griffithsin (GRFT), a novel anti-HIV protein, was isolated from an aqueous extract of the red
alga Griffithsia sp. The 121-amino acid sequence of GRFT has been determined, and …
alga Griffithsia sp. The 121-amino acid sequence of GRFT has been determined, and …
[HTML][HTML] Griffithsin, a highly potent broad-spectrum antiviral lectin from red algae: From discovery to clinical application
C Lee - Marine drugs, 2019 - mdpi.com
Virus entry into a susceptible host cell is the first step in the formation of all viral diseases.
Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated …
Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated …