[HTML][HTML] Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
S Günther, PYA Reinke, Y Fernández-García, J Lieske… - Science, 2021 - science.org
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous
human suffering. To date, no effective drug is available to directly treat the disease. In a …
human suffering. To date, no effective drug is available to directly treat the disease. In a …
Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19
ABSTRACT A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent
responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan1-4 …
responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan1-4 …
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent
responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main …
responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main …
Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits
GG Rossetti, MA Ossorio, S Rempel, A Kratzel… - Scientific reports, 2022 - nature.com
Mpro, the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), is essential for the viral life cycle. Accordingly, several groups have performed in …
CoV-2), is essential for the viral life cycle. Accordingly, several groups have performed in …
Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro
Recently, Zhang and colleagues published a study in Science which reports about the
crystal structure of the main protease (Mpro, 3CLpro) of SARS-CoV-2 1. The authors …
crystal structure of the main protease (Mpro, 3CLpro) of SARS-CoV-2 1. The authors …
Perspectives on SARS-CoV-2 main protease inhibitors
The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease
Highlights•The main protease, known as M pro, is encoded by the viral genome and is
essential for viral replication.•The effective target for drug development has been the M …
essential for viral replication.•The effective target for drug development has been the M …
Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
A Shitrit, D Zaidman, O Kalid, I Bloch, D Doron… - Scientific reports, 2020 - nature.com
The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of
antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C‐like protease …
antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C‐like protease …
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …