Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

Transcriptional enhancers are regulatory DNA elements that underlie the specificity and
dynamic patterns of gene expression. Over the past decade, large-scale functional …

Enhancers are non-coding DNA elements that function in cis to regulate transcription from
nearby genes. Through direct interactions with gene promoters, enhancers give rise to …

Non-coding transcriptional regulatory elements are critical for controlling the spatiotemporal
expression of genes. Here, we demonstrate that the sizes and number of enhancers linked …

Understanding the complexity of the human brain and its functional diversity remain a major
challenge. Distinct anatomical regions are involved in an array of processes, including …

In recent years, studies of cis-regulatory mechanisms have evolved from a predominant
focus on promoter regions to the realization that spatial and temporal gene regulation is …

Large-scale sequencing studies discovered substantial genetic variants occurring in
enhancers which regulate genes via long range chromatin interactions. Importantly, such …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Enhancers are distally located genomic cis-regulatory elements that integrate
spatiotemporal cues to coordinate gene expression in a tissue-specific manner during …

Background Non-coding gene regulatory enhancers are essential to transcription in
mammalian cells. As a result, a large variety of experimental and computational strategies …