DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …

Despite much research, our understanding of the architecture and cis-regulatory elements of
human promoters is still lacking. Here, we devised a high-throughput assay to quantify the …

Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …

Transcriptional promoters comprise one of many classes of eukaryotic transcriptional
regulatory elements. Identification and characterization of these elements are vital to …

How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene
expression remains unclear, largely because past studies using native and engineered …

Sequence-specific transcription factors (TFs) are important to genetic regulation in all
organisms because they recognize and directly bind to regulatory regions on DNA. Here, we …

Transcription factors are key cellular components that control gene expression: their
activities determine how cells function and respond to the environment. Currently, there is …

Gene expression is controlled by sequence-specific transcription factors (TFs), which bind to
regulatory sequences in DNA. TF binding occurs in nucleosome-depleted regions of DNA …

Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) has
become the dominant technique for mapping transcription factor (TF) binding regions …

Background Combinatorial interaction of transcription factors (TFs) is important for gene
regulation. Although various genomic datasets are relevant to this issue, each dataset …