Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance, cancer initiating cells (CICs) and …

Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …

Abstract Approximately 70− 75% of breast cancers express the estrogen receptor (ER),
indicating a level of dependence on estrogen for growth. Endocrine therapy is an important …

Aberrant activation of the PI3K/Akt/mTOR pathway is found in many types of cancer and thus
plays a major role in breast cancer cell proliferation and anti-cancer drug resistance. The …

Epidermal growth factor (EGF) receptors (EGFRs) and signaling pathways activated by
these receptors have been associated with development of breast cancer as well as its …

Breast cancer is one of the most prevalent and devastating malignant diseases in women
worldwide. Fortunately, while breast cancer incidence is still increasing, its death rate is …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

Simple Summary Breast cancers are broadly classified into two subtypes: estrogen receptor-
positive and estrogen receptor-negative. Approximately 70% of breast cancers are estrogen …

Aberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many
human malignancies including breast cancer. Since the discovery of EGF in 1960's and its …