Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis

CC Lee, CJ Yu, SS Panda, KC Chen, KH Liang… - Journal of Translational …, 2023 - Springer
Background Epithelial cell adhesion molecule (EpCAM) is known to highly expression and
promotes cancer progression in many cancer types, including colorectal cancer. While …

Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells

KH Liang, HC Tso, SH Hung, II Kuan, JK Lai, FY Ke… - Cancer letters, 2018 - Elsevier
Epithelial cell adhesion molecule (EpCAM) is highly expressed in colon cancers, but its role
in cancer progression remains to be elucidated. In this work, we found that the extracellular …

EpCAM associates with integrin and regulates cell adhesion in cancer cells

J Yang, T Isaji, G Zhang, F Qi, C Duan, T Fukuda… - Biochemical and …, 2020 - Elsevier
The epithelial cell adhesion molecule (EpCAM) is one of the most frequently and intensely
expressed of tumor-associated antigens, but the role that EpCAM plays in the proliferation …

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside

Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …

Concise review: aggressive colorectal cancer: role of epithelial cell adhesion molecule in cancer stem cells and epithelial-to-mesenchymal transition

M Boesch, G Spizzo, A Seeber - Stem cells translational …, 2018 - academic.oup.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of
various attempts to ameliorate outcome by escalating treatment, significant improvement is …

Revisiting the roles of pro-metastatic EpCAM in cancer

MA Mohtar, SE Syafruddin, SN Nasir, TY Low - Biomolecules, 2020 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a
tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal …

RETRACTED ARTICLE: EpCAM: A Potential Antimetastatic Target for Gastric Cancer

W Du, H Ji, S Cao, L Wang, F Bai, J Liu… - Digestive Diseases and …, 2010 - Springer
Purpose Epithelial cellular adhesion molecule (EpCAM) is an attractive immunotherapeutic
target to overcome metastasis of a variety of epithelium-oriented cancers. Edrecolomab, one …

[HTML][HTML] An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

MY Liao, JK Lai, MYP Kuo, RM Lu, CW Lin, PC Cheng… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Epithelial cell adhesion molecule (EpCAM) is known to be overexpressed in epithelial
cancers associated with enhanced malignant potential, particularly colorectal carcinoma …

The emerging role of EpCAM in cancer and stem cell signaling

M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface …

EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer

D Wenqi, W Li, C Shanshan, C Bei, Z Yafei… - Journal of cancer …, 2009 - Springer
Purpose To identify the role of epithelial cellular adhesion molecule (EpCAM) in gastric
cancer growth and explore the potential value of EpCAM monoclonal antibody as new …