Age-associated changes in the T cell compartment are well described. However, limitations
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …

The efficacy of the adaptive immune response declines markedly with age, but the cell-
intrinsic mechanisms driving immune aging in humans remain poorly understood. Immune …

Healthy immune aging is in part determined by how well the sizes of naïve T cell
compartments are being maintained with advancing age. Throughout adult life …

Age-associated changes in CD4 T-cell functionality have been linked to chronic
inflammation and decreased immunity. However, a detailed characterization of CD4 T cell …

CD8+ T cells provide robust antiviral immunity, but how epitope-specific T cells evolve
across the human lifespan is unclear. Here we defined CD8+ T cell immunity directed at the …

Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in
response to cytokines. However, the cytokine responses in memory T cells remain largely …

Efficient immune responses rely on heterogeneity, which in CD8+ T cells, amongst other
mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing …

Human aging is associated with a profound loss of thymus productivity, yet naïve T
lymphocytes still maintain their numbers by division in the periphery for many years. The …

The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …