Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Rationale: There are no randomized controlled trials comparing different oxygenation
targets for intensive care unit (ICU) patients. Objectives: To determine whether a …

Background Although low oxygen saturations are generally regarded as deleterious, recent
studies in ICU patients have shown that a liberal oxygen strategy increases mortality …

Importance Among critically ill adults, randomized trials have not found oxygenation targets
to affect outcomes overall. Whether the effects of oxygenation targets differ based on an …

Rationale: Supplemental oxygen is widely administered to ICU patients, but appropriate
oxygenation targets remain unclear. Objectives: This study aimed to determine whether a …

Objectives: Conservative oxygen therapy is aimed at the prevention of harm by iatrogenic
hyperoxia while preserving adequate tissue oxygenation. Our aim was to study the …

Objectives: High fractions of inspired oxygen may augment lung damage to exacerbate lung
injury in patients with acute respiratory distress syndrome. Participants enrolled in Acute …

Background Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU)
are treated with supplemental oxygen, but the benefits and harms of different oxygenation …

Importance Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal
oxygenation targets are unknown. Objective To determine whether a low-normal Pao 2 …

Background Patients who are undergoing mechanical ventilation in the intensive care unit
(ICU) often receive a high fraction of inspired oxygen (Fio 2) and have a high arterial oxygen …