[HTML][HTML] Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

S Xiong, W Liu, Y Zhou, Y Mo, Y Liu, X Chen… - Asian journal of …, 2020 - Elsevier
Abstract Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of
plants, exhibits neuroprotective activities against Parkinson's disease (PD). However …

Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress

R Pangeni, S Sharma, G Mustafa, J Ali… - Nanotechnology, 2014 - iopscience.iop.org
Resveratrol, a potent natural antioxidant, possesses a wide range of pharmacological
activities, but its oral bioavailability is very low due to its extensive hepatic and presystemic …

Improved neuroprotective effect of resveratrol nanoparticles as evinced by abrogation of rotenone-induced behavioral deficits and oxidative and mitochondrial …

S Palle, P Neerati - Naunyn-Schmiedeberg's Archives of Pharmacology, 2018 - Springer
The objective of the present study was to evaluate the protective effect of resveratrol
nanoparticles (NRSV) against rotenone-induced neurodegeneration in rats. NRSV were …

Preparation and in-vitro/in-vivo characterization of trans-resveratrol nanocrystals for oral administration

SK Singh, V Makadia, S Sharma, M Rashid… - Drug delivery and …, 2017 - Springer
Abstract Trans-resveratrol (t-RES) is a natural polyphenolic compound with extensive
therapeutic activities; however, its clinical application is circumscribed due to its poor …

The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

B Fonseca-Santos, M Chorilli - International journal of pharmaceutics, 2020 - Elsevier
Neurological disorders have been growing in recent years and are highly prevalent globally.
Resveratrol (RES) is a natural product from plant sources such as grape skins. This …

Neuroprotection by resveratrol: A review on brain delivery strategies for Alzheimer's and Parkinson's disease

V Chinraj, S Raman - Journal of Applied Pharmaceutical Science, 2022 - japsonline.com
Alzheimer's (AD) and Parkinson's (PD) are the two most common neurodegenerative
disorders that affect millions of people worldwide, but their therapeutic opportunities are …

Resveratrol brain delivery for neurological disorders prevention and treatment

S Andrade, MJ Ramalho, MC Pereira… - Frontiers in …, 2018 - frontiersin.org
Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes,
mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have …

Preparation and optimization of resveratrol nanosuspensions by antisolvent precipitation using Box-Behnken design

J Hao, Y Gao, J Zhao, J Zhang, Q Li, Z Zhao, J Liu - Aaps Pharmscitech, 2015 - Springer
Resveratrol, a natural polyphenolic component, has inspired considerable interest for its
extensive physiological activities. However, the poor solubility of resveratrol circumscribes …

Enhanced neuroprotective effects of resveratrol delivered by nanoparticles on hydrogen peroxide-induced oxidative stress in rat cortical cell culture

X Lu, H Xu, B Sun, Z Zhu, D Zheng… - Molecular Pharmaceutics, 2013 - ACS Publications
Resveratrol (RES) has recently been reported as a potential antioxidant in treatment of
ischemia/reperfusion injury through attenuating oxidative stress and apoptosis. However …

Enhancement of blood–brain barrier penetration and the neuroprotective effect of resveratrol

N Katila, R Duwa, S Bhurtel, S Khanal… - Journal of Controlled …, 2022 - Elsevier
Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons within the substantia nigra. The specific molecular …