PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis

M Su, F Chen, D Han, M Song… - Journal of Proteome …, 2024 - ACS Publications
Severe acute pancreatitis (SAP) is a highly fatal abdominal emergency, and its association
with protein arginine methyltransferase 7 (PRMT7), the sole known type III enzyme …

METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1

F Chen, M Su, D Han, Y Wang, M Song - International …, 2024 - Elsevier
Abstract Methyltransferase-like 14 (METTL14) is implicated in the regulation of various
inflammatory disorders. However, its function and molecular mechanism in severe acute …

lnc‐MRGPRF‐6: 1 Promotes ox‐LDL‐Induced Macrophage Ferroptosis via Suppressing GPX4

Z You, X Ye, M Jiang, N Gu… - Mediators of inflammation, 2023 - Wiley Online Library
Background. Ferroptosis, a newly discovered mode of cell death, emerges as a new target
for atherosclerosis (AS). Long noncoding RNAs (lncRNAs) are involved in the regulation of …

[HTML][HTML] Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of …

J He, X Hou, J Wu, K Wang, X Qi, Z Wei… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own,
but the mortality rate dramatically increases when it progresses to severe acute pancreatitis …

ETD-Based Proteomic Profiling Improves Arginine Methylation Identification and Reveals Novel PRMT5 Substrates

L Lu, Z Ye, R Zhang, JV Olsen, Y Yuan… - Journal of Proteome …, 2024 - ACS Publications
Protein arginine methylations are important post-translational modifications (PTMs) in
eukaryotes, regulating many biological processes. However, traditional collision-based …

Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression

W Deng, J Ai, W Zhang, Z Zhou, M Li, L Yan… - Journal of translational …, 2023 - Springer
Background The hepatitis B virus X (HBx) protein is an established cause of hepatitis B virus
(HBV)-induced hepatocellular carcinoma (HCC). Whether arginine methylation regulates …

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation

N Haghandish, RM Baldwin, A Morettin… - Molecular biology of …, 2019 - Am Soc Cell Biol
Protein arginine methyltransferases (PRMTs) are a family of enzymes that modify proteins by
methylating the guanidino nitrogen atoms of arginine residues to regulate cellular processes …

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis

Y Qin, Q Hu, J Xu, S Ji, W Dai, W Liu, W Xu… - Cell Communication and …, 2019 - Springer
Background The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been
reported to play vital roles in a wide range of cellular processes, such as gene transcription …

Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats

X Xiang, M Xu, L Liu, N Meng, Y Lei, Y Feng… - Scientific Reports, 2024 - nature.com
Ferroptosis is closely associated with inflammatory diseases, including acute pancreatitis
(AP); however, the involvement of ferroptosis in hypertriglyceridemic pancreatitis (HTGP) …

Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis

L Yang, F Ye, J Liu, DJ Klionsky, D Tang, R Kang - Autophagy, 2023 - Taylor & Francis
Acute pancreatitis (AP) is an abdominal inflammatory disease initiated by damaged
pancreatic acinar cells and developed by systemic inflammation. SQSTM1 (sequestosome …