Preclinical efficacy and safety of novel SNAT against SARS-CoV-2 using a hamster model

LR Pokhrel, F Williams, PP Cook, D O'Rourke… - Drug Delivery and …, 2022 - Springer
To address the unprecedented global public health crisis due to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), we designed and developed a novel antiviral nano …

[HTML][HTML] Evaluating Molecular Mechanism of Viral Inhibition of Aerosolized Smart Nano-Enabled Antiviral Therapeutic (SNAT) on SARS-CoV-2-Infected Hamsters

AN Bauer, JF Williams, LR Pokhrel, S Garcia… - Toxics, 2024 - mdpi.com
Smart Nano-enabled Antiviral Therapeutic (SNAT) is a promising nanodrug that previously
demonstrated efficacy in preclinical studies to alleviate SARS-CoV-2 pathology in hamsters …

Nafamostat Mesylate in lipid carrier for nasal SARS-CoV2 titer reduction in a hamster model

L Cornelissen, E Hoefsmit, D Rao, J Lijnsvelt… - bioRxiv, 2020 - biorxiv.org
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has been responsible for
the largest pandemic in recent decades. After seemingly being in control due to consequent …

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

AA Ordonez, CK Bullen, AF Villabona-Rueda… - Communications …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

Broad antiviral and anti‐inflammatory efficacy of nafamostat against SARS‐CoV‐2 and seasonal coronaviruses in primary human bronchiolar epithelia

BF Niemeyer, CM Miller, C Ledesma‐Feliciano… - Nano …, 2022 - Wiley Online Library
Antiviral strategies that target host systems needed for SARS‐CoV‐2 replication and
pathogenesis may have therapeutic potential and help mitigate resistance development …

Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant

G Gupta, B Hamawandi, DJ Sheward… - … in Bioengineering and …, 2022 - frontiersin.org
Silver (Ag) is known to possess antimicrobial properties which is commonly attributed to
soluble Ag ions. Here, we showed that Ag nanoparticles (NPs) potently inhibited SARS-CoV …

Sulforaphane exhibits in vitro and in vivo antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses

AA Ordonez, CK Bullen, AF Villabona-Rueda… - BioRxiv, 2021 - biorxiv.org
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

Nanoparticle-based strategies to combat COVID-19

R Medhi, P Srinoi, N Ngo, HV Tran… - ACS Applied Nano …, 2020 - ACS Publications
Coronavirus disease 2019 (COVID-19) is the worst pandemic disease of the current
millennium. This disease is caused by the highly contagious severe acute respiratory …

Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses

SY Chang, KY Huang, TL Chao, HC Kao, YH Pang… - Scientific reports, 2021 - nature.com
A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5
ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and …

Marine sponge is a promising natural source of anti-SARS-CoV-2 scaffold

AM Hamoda, B Fayed, NS Ashmawy… - Frontiers in …, 2021 - frontiersin.org
The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for
novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) …