The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

The central nervous system (CNS) is a sanctuary site and is protected by various barriers.
These regulate brain homeostasis and the transport of endogenous and exogenous …

Being the most delicate organ of the body, the brain is protected against potentially toxic
substances by the blood-brain barrier (BBB), which restricts the entry of most …

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry.
However, this growth is blocked by the problem of the blood–brain barrier (BBB). Essentially …

The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the
brain from the periphery. Therefore, discovery of new modalities allowing for effective …

The brain is a delicate organ, and nature has very efficiently protected it. The brain is
shielded against potentially toxic substances by the presence of two barrier systems: the …

In 1996, we are half-way through the Decade of the Brain, yet we still have few effective
treatments for major disorders of the central nervous system. These include affective …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

While neurodegenerative diseases and cancers are on the rise, treatments for diseases of
the central nervous system (CNS) remain limited. The blood brain barrier (BBB) poses the …

The blood–brain barrier (BBB) denies many therapeutic agents access to brain tumours and
other diseases of the central nervous system (CNS). Despite remarkable advances in our …