Transposable elements (TEs) are major contributors of genetic material in mammalian
genomes. These often include binding sites for architectural proteins, including the …

Abstract Background Transposable elements (TEs) make up half of mammalian genomes
and shape genome regulation by harboring binding sites for regulatory factors. These …

Chromatin looping is important for gene regulation, and studies of 3D chromatin structure
across species and cell types have improved our understanding of the principles governing …

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing …

Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as
the protein anchors and determinants of 3D genome organization. Conversely, chromatin …

Three-dimensional genome structure plays an important role in gene regulation. Globally,
chromosomes are organized into active and inactive compartments while, at the gene level …

Cancers and developmental disorders are associated with alterations in the 3D genome
architecture in space and time (the fourth dimension). Mammalian 3D genome organization …

Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

Background The organization of chromatin in the nucleus plays an essential role in gene
regulation. About half of the mammalian genome comprises transposable elements. Given …