Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
[HTML][HTML] Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
BH Mullin, J Tickner, K Zhu, J Kenny, S Mullin… - Genome biology, 2020 - Springer
Background Osteoporosis is a complex disease with a strong genetic contribution. A recently
published genome-wide association study (GWAS) for estimated bone mineral density …
published genome-wide association study (GWAS) for estimated bone mineral density …
An atlas of genetic influences on osteoporosis in humans and mice
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …
[HTML][HTML] Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture
SK Kim - PloS one, 2018 - journals.plos.org
Low bone mineral density (BMD) leads to osteoporosis, and is a risk factor for bone
fractures, including stress fractures. Using data from UK Biobank, a genome-wide …
fractures, including stress fractures. Using data from UK Biobank, a genome-wide …
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Quantitative ultrasound of the heel captures heel bone properties that independently predict
fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be …
fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be …
[HTML][HTML] Integrating GWAS and co-expression network data identifies bone mineral density genes SPTBN1 and MARK3 and an osteoblast functional module
GM Calabrese, LD Mesner, JP Stains, SM Tommasini… - Cell systems, 2017 - cell.com
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Genome-
wide association studies (GWAS) for BMD have identified dozens of associations; yet, the …
wide association studies (GWAS) for BMD have identified dozens of associations; yet, the …
[HTML][HTML] Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2
Osteoporotic fractures are a major cause of morbidity and mortality in ageing populations.
Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have …
Osteoporosis, defined as low bone mineral density (BMD) and associated fractures, have …
[HTML][HTML] An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related …
Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …
Genome-wide association studies (GWAS) have become an unbiased approach to identify …
[HTML][HTML] Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone …
Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different
relative contributions of genetic and environmental influences. To quantify the degree to …
relative contributions of genetic and environmental influences. To quantify the degree to …
The genetic architecture of osteoporosis and fracture risk
K Trajanoska, F Rivadeneira - Bone, 2019 - Elsevier
Osteoporosis and fracture risk are common complex diseases, caused by an interaction of
numerous disease susceptibility genes and environmental factors. With the advances in …
numerous disease susceptibility genes and environmental factors. With the advances in …