How ITD Insertion Sites Orchestrate the Biology and Disease of FLT3-ITD-Mutated Acute Myeloid Leukemia
TR Haage, B Schraven, D Mougiakakos, T Fischer - Cancers, 2023 - mdpi.com
Simple Summary FLT3 gene mutations are among the most common genetic aberrations
detected in AML and occur with a frequency of approximately 30%, mainly as internal …
detected in AML and occur with a frequency of approximately 30%, mainly as internal …
Targeting oncogenic signaling in mutant FLT3 acute myeloid leukemia: the path to least resistance
The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …
resulted in the development of molecularly-targeted treatment strategies designed to …
Point Mutations in the FLT3-ITD Region Are Rare but Recurrent Alterations in Adult AML and Associated With Concomitant KMT2A-PTD
FLT3-ITD mutations are common druggable alterations in patients with acute myeloid
leukemia (AML) and associated with poor prognosis. Beside typical ITD mutations, point …
leukemia (AML) and associated with poor prognosis. Beside typical ITD mutations, point …
Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
S Kayser, RF Schlenk, MC Londono… - Blood, The Journal …, 2009 - ashpublications.org
To evaluate internal tandem duplication (ITD) insertion sites and length as well as their
clinical impact in younger adult patients with FLT3-ITD–positive acute myeloid leukemia …
clinical impact in younger adult patients with FLT3-ITD–positive acute myeloid leukemia …
Modulation of FLT3-ITD localization and targeting of distinct downstream signaling pathways as potential strategies to overcome FLT3-inhibitor resistance
M Fleischmann, M Fischer, U Schnetzke, C Fortner… - Cells, 2021 - mdpi.com
OBJECTIVES: Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3)
represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are …
represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are …
[HTML][HTML] Prognostic impact of insertion site in acute myeloid leukemia (AML) with FLT3 internal tandem duplication: results from the ratify study (Alliance 10603)
FG Rücker, L Du, TJ Blätte, A Benner, J Krzykalla… - Blood, 2018 - Elsevier
Introduction: Internal tandem duplication of the FLT3 gene (FLT3-ITD), resulting in
duplication of 3 to more than hundreds of nucleotides, are present in approximately 25% of …
duplication of 3 to more than hundreds of nucleotides, are present in approximately 25% of …
Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis
DJ Young, B Nguyen, R Zhu, J Seo, L Li… - Blood …, 2021 - ashpublications.org
The FMS-like tyrosine kinase 3 (FLT-3) is the most frequently mutated gene in acute myeloid
leukemia (AML), a high-risk feature, and now the target of tyrosine kinase inhibitors (TKIs) …
leukemia (AML), a high-risk feature, and now the target of tyrosine kinase inhibitors (TKIs) …
FLT3‐ITD mutations in acute myeloid leukaemia–molecular characteristics, distribution and numerical variation
C Engen, M Hellesøy, T Grob, A Al Hinai… - Molecular …, 2021 - Wiley Online Library
Recurrent somatic internal tandem duplications (ITD) in the FMS‐like tyrosine kinase 3
(FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia …
(FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia …
Treatment with FLT3 inhibitor in patients with FLT3‐mutated acute myeloid leukemia is associated with development of secondary FLT3–tyrosine kinase domain …
Y Alvarado, HM Kantarjian, R Luthra, F Ravandi… - Cancer, 2014 - Wiley Online Library
BACKGROUND FLT3–internal tandem duplication (ITD) mutations are found in
approximately 30% of patients with acute myeloid leukemia (AML). FLT3 inhibitors have …
approximately 30% of patients with acute myeloid leukemia (AML). FLT3 inhibitors have …
FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in …
The prognostic impact of tyrosine kinase domain (TKD) mutations of the fms-like tyrosine
kinase-3 (FLT3) gene in acute myeloid leukemia (AML) is currently uncertain. To resolve this …
kinase-3 (FLT3) gene in acute myeloid leukemia (AML) is currently uncertain. To resolve this …