Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
General rules for functional microRNA targeting
The functional rules for microRNA (miRNA) targeting remain controversial despite their
biological importance because only a small fraction of distinct interactions, called site types …
biological importance because only a small fraction of distinct interactions, called site types …
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of
miRNA targets remains a major challenge. Most target prediction and discovery relies on …
miRNA targets remains a major challenge. Most target prediction and discovery relies on …
MicroRNA targeting specificity in mammals: determinants beyond seed pairing
Mammalian microRNAs (miRNAs) pair to 3′ UTRs of mRNAs to direct their
posttranscriptional repression. Important for target recognition are∼ 7 nt sites that match the …
posttranscriptional repression. Important for target recognition are∼ 7 nt sites that match the …
ComiR: combinatorial microRNA target prediction tool
C Coronnello, PV Benos - Nucleic acids research, 2013 - academic.oup.com
ComiR is a web tool for combinatorial microRNA (miRNA) target prediction. Given an
messenger RNA (mRNA) in human, mouse, fly or worm genomes, ComiR computes the …
messenger RNA (mRNA) in human, mouse, fly or worm genomes, ComiR computes the …
Most mammalian mRNAs are conserved targets of microRNAs
RC Friedman, KKH Farh, CB Burge… - Genome research, 2009 - genome.cshlp.org
MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …
transcriptional repression. Many sites that match the miRNA seed (nucleotides 2–7) …
The biochemical basis of microRNA targeting efficacy
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
[HTML][HTML] MicroRNA target recognition: insights from transcriptome-wide non-canonical interactions
H Seok, J Ham, ES Jang, SW Chi - Molecules and cells, 2016 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs (∼ 22 nucleotides) regulating gene
expression at the post-transcriptional level. By directing the RNA-induced silencing complex …
expression at the post-transcriptional level. By directing the RNA-induced silencing complex …
IsomiRs: expanding the miRNA repression toolbox beyond the seed
MicroRNAs (miRNAs) are a class of small non-coding RNAs that play increasingly
appreciated roles in gene regulation. In animals, miRNAs silence gene expression by …
appreciated roles in gene regulation. In animals, miRNAs silence gene expression by …
Prediction of both conserved and nonconserved microRNA targets in animals
X Wang, IM El Naqa - Bioinformatics, 2008 - academic.oup.com
Motivation: MicroRNAs (miRNAs) are involved in many diverse biological processes and
they may potentially regulate the functions of thousands of genes. However, one major issue …
they may potentially regulate the functions of thousands of genes. However, one major issue …