Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …

This protocol demonstrates the capability of low-field electron paramagnetic resonance
(EPR)-based techniques in combination with functional paramagnetic probes to provide …

Significance: A key role of the tumor microenvironment (TME) in cancer progression,
treatment resistance, and as a target for therapeutic intervention is increasingly appreciated …

Inorganic phosphate (Pi) is an essential nutrient to living organisms. It is required as a
component of the energy metabolism, kinase/phosphatase signaling and in the formation …

Purpose The ability to assess the extracellular pH (pHe) is an important issue in oncology,
because extracellular acidification is associated with tumor aggressiveness and resistance …

Acid production and transport are currently being studied to identify new targets for efficient
cancer treatment, as subpopulations of tumor cells frequently escape conventional therapy …

In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. The clinical outcome for osteosarcoma remains discouraging despite …

The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two
of the most characterized properties of the TME are acidosis and hypoxia, both of which are …

Gliomas maintain an acidic extracellular pH (pHe), which promotes tumor growth and builds
resistance to therapy. Given evidence that acidic pHe beyond the tumor core indicates …