Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

Radicals are species containing one or more unpaired electrons. The oxygen radical
superoxide (O2‐) and the non‐radical oxidant hydrogen peroxide (H2O2) are produced …

Many evidences indicate that oxidative stress plays a significant role in a variety of human
disease states, including neurodegenerative diseases. Iron is an essential metal for almost …

Oxidative stress has been consistently linked to ageing-related neurodegenerative
diseases. Neurodegenerative diseases are characterized by progressive dysfunction and …

1972 BUTTERFIELD latter radicals, in turn, react with other lipid-resident allylic hydrogen
atoms to form lipid hydroperoxides and additional carbon-centered lipid radicals …

The brain and nervous system are prone to oxidative stress, and are inadequately equipped
with antioxidant defense systems to prevent 'ongoing'oxidative damage, let alone the extra …

ANTIOXIDANTS & REDOX SIGNALING Volume 5, Number 5, 2003© Mary Ann Liebert, Inc.
free radicals (4, 13, 40). Iron-and copper-induced free radical damage may play a …

Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative
disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important …

Aging and neurodegenerative diseases share oxidative stress cell damage and depletion of
endogenous antioxidants as mechanisms of injury, phenomena that are occurring at …

Oxidative stress (OS) has been implicated in the pathophysiology of many neurological,
particularly neurodegenerative diseases. OS can cause cellular damage and subsequent …