Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …

Cytochromes P450 enzymes, especially CYP3A4, are responsible for metabolizing a broad
range of anticancer drugs. Combination therapy is common in patients with cancer, which …

Purpose: The purpose is to identify the demographic, physiologic, and inheritable factors
that influence CYP3A activity in cancer patients Experimental Design: A total of 134 patients …

CYP3A isozymes participate in the metabolism of 45–60% of currently used drugs and of a
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …

The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …

CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal
CYP protein and they are involved in the metabolism of 45–60% of all currently used drugs …

A 2016 study proposed induction of the cytochrome P450 (CYP) enzyme CYP3A5 as a key
mechanism for chemotherapy resistance and suggested CYP3A5 as a promising …

Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …

The genetic component of the inter-individual variability in CYP3A4 activity has been
estimated to be between 60% and 90%, but the underlying genetic factors remain largely …

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …