SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

[HTML][HTML] SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

D Wendisch, O Dietrich, T Mari, S von Stillfried… - Cell, 2021 - cell.com
Summary COVID-19-induced" acute respiratory distress syndrome"(ARDS) is associated
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

[HTML][HTML] A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

TM Delorey, CGK Ziegler, G Heimberg, R Normand… - Biorxiv, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute
lung injury and acute respiratory distress syndrome, or direct complications resulting in …

Innate immune cell activation causes lung fibrosis in a humanized model of long COVID

L Cui, Z Fang, CM De Souza, T Lerbs… - Proceedings of the …, 2023 - National Acad Sciences
COVID-19 remains a global pandemic of an unprecedented magnitude with millions of
people now developing “COVID lung fibrosis.” Single-cell transcriptomics of lungs of patients …

Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2

L Heydemann, M Ciurkiewicz, G Beythien… - Nature …, 2023 - nature.com
COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC).
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …

Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung

TTH Wu, KJ Travaglini, A Rustagi, D Xu… - Journal of Experimental …, 2024 - rupress.org
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …

SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2

KM Littlefield, RO Watson, JM Schneider… - PLoS …, 2022 - journals.plos.org
As of January 2022, at least 60 million individuals are estimated to develop post-acute
sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome …

[HTML][HTML] Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

A Pizzorno, B Padey, T Julien, S Trouillet-Assant… - Cell Reports …, 2020 - cell.com
In the current COVID-19 pandemic context, proposing and validating effective treatments
represents a major challenge. However, the scarcity of biologically relevant pre-clinical …

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

C Margaroli, P Benson, NS Sharma, MC Madison… - Cell Reports …, 2021 - cell.com
Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress
syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is …