Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

MI Barton, SA MacGowan, MA Kutuzov, O Dushek… - Elife, 2021 - elifesciences.org
(RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in
the RBD are present in SARS-CoV-2 variants of concern that have emerged independently …

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

H Othman, Z Bouslama, JT Brandenburg… - Biochemical and …, 2020 - Elsevier
The spread of COVID-19 caused by the SARS-CoV-2 outbreak has been growing since its
first identification in December 2019. The publishing of the first SARS-CoV-2 genome made …

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

F Ye, X Lin, Z Chen, F Yang, S Lin, J Yang… - … and Targeted Therapy, 2021 - nature.com
Abstract SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human
angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 …

Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective

S Borkotoky, D Dey, Z Hazarika - Molecular biology reports, 2023 - Springer
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
caused millions of infections and deaths worldwide since its discovery in late 2019 in …

[PDF][PDF] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

P Han, L Li, S Liu, Q Wang, D Zhang, Z Xu, P Han, X Li… - Cell, 2022 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with
many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron …

Molecular mechanism of the N501Y mutation for enhanced binding between SARS-CoV-2's spike protein and human ACE2 receptor

B Luan, H Wang, T Huynh - BioRxiv, 2021 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) has been an ongoing global pandemic for
over a year. Recently, an emergent SARS-CoV-2 variant (B. 1.1. 7) with an unusually large …

V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding …

J Ou, Z Zhou, R Dai, J Zhang, S Zhao, X Wu… - Journal of …, 2021 - Am Soc Microbiol
The current pandemic of COVID-19 is caused by a novel coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein receptor …

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

S Chakraborty - Biochemical and biophysical research communications, 2021 - Elsevier
The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates
host cell entry. The objective of the work is to identify SARS-CoV2 spike variants that …

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - BioRxiv, 2021 - biorxiv.org
ABSTRACT SARS-CoV-2 is spreading around the world for the past year. Enormous efforts
have been taken to understand its mechanism of transmission. It is well established now that …

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

A Singh, G Steinkellner, K Köchl, K Gruber… - Scientific reports, 2021 - nature.com
Since the worldwide outbreak of the infectious disease COVID-19, several studies have
been published to understand the structural mechanism of the novel coronavirus SARS-CoV …