Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Understanding the difference in genetic regulation of gene expression between brain and
blood is important for discovering genes for brain-related traits and disorders. Here, we …
blood is important for discovering genes for brain-related traits and disorders. Here, we …
On the outside, looking in: a review and evaluation of the comparability of blood and brain “‐omes”
DS Tylee, DM Kawaguchi… - American Journal of …, 2013 - Wiley Online Library
In this article, we review studies detailing the correspondence between peripheral blood and
brain tissue across various domains of high‐throughput‐omic analysis in order to provide a …
brain tissue across various domains of high‐throughput‐omic analysis in order to provide a …
Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type
Background Individual genotypes at specific loci can result in different patterns of DNA
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
A fundamental challenge in the post-genome era is to understand and annotate the
consequences of genetic variation, particularly within the context of human tissues. We …
consequences of genetic variation, particularly within the context of human tissues. We …
Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci
Most genetic variants identified in genome-wide association studies (GWASs) of complex
traits are thought to act by affecting gene regulation rather than directly altering the protein …
traits are thought to act by affecting gene regulation rather than directly altering the protein …
Leveraging DNA-methylation quantitative-trait loci to characterize the relationship between methylomic variation, gene expression, and complex traits
Characterizing the complex relationship between genetic, epigenetic, and transcriptomic
variation has the potential to increase understanding about the mechanisms underpinning …
variation has the potential to increase understanding about the mechanisms underpinning …
Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution
DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …