The emerging clinical application of m6A RNA modification in inflammatory bowel disease and its associated colorectal cancer

X Xu, J Huang, DKW Ocansey, Y Xia… - Journal of …, 2021 - Taylor & Francis
Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most
widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) …

[HTML][HTML] m6A modification in inflammatory bowel disease provides new insights into clinical applications

J Zhang, B Song, Y Zeng, C Xu, L Gao, Y Guo… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …

A broad m6A modification landscape in inflammatory bowel disease

K Nie, J Yi, Y Yang, M Deng, Y Yang… - Frontiers in cell and …, 2022 - frontiersin.org
Background and Aims: N6-Methyladenosine (m6A) is the most common post-transcriptional
modification on eukaryotic mRNA, affecting the mRNA's fate. The role of m6A regulation in …

[HTML][HTML] Role of m6A modification in immune microenvironment of digestive system tumors

C Li, M Zhu, J Wang, H Wu, Y Liu, D Huang - Biomedicine & …, 2023 - Elsevier
Digestive system tumors are huge health problem worldwide, largely attributable to poor
dietary choices. The role of RNA modifications in cancer development is an emerging field of …

The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer

H Qiao, L Liu, J Chen, B Shang, L Wang - Medical Oncology, 2022 - Springer
Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are
some of the most common malignant tumors that are prone to distant metastasis. Its high …

Immune infiltration of ulcerative colitis and detection of the m6A subtype

C Gu, J Wu, W Zhang, Y Yao, W Yan… - Journal of …, 2022 - Wiley Online Library
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent colon
inflammation. N6‐methyladenosine (m6A) methylation is one of the most prevalent RNA …

[HTML][HTML] The roles and mechanism of m6A RNA methylation regulators in cancer immunity

L Chen, Y He, J Zhu, S Zhao, S Qi, X Chen… - Biomedicine & …, 2023 - Elsevier
Abstract N 6-methyladenosine (m 6 A), the most common internal modification in RNA, can
be regulated by three types of regulators, including methyltransferases (writers) …

The emerging role of m6A modification in regulating the immune system and autoimmune diseases

Y Wang, L Li, J Li, B Zhao, G Huang, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Over the past several decades, RNA modifications have rapidly emerged as an
indispensable topic in epitranscriptomics. N6-methyladenosine (m6A), namely, methylation …

N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications

J Luo, T Xu, K Sun - Frontiers in cell and developmental biology, 2021 - frontiersin.org
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be
installed by the methyltransferase complex and removed by demethylases, which are …

m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

X Jiang, Z Jin, Y Yang, X Zheng, S Chen… - Frontiers in …, 2023 - frontiersin.org
N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The
dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and …