Developmental dynamics of lncRNAs across mammalian organs and species

I Sarropoulos, R Marin, M Cardoso-Moreira… - Nature, 2019 - nature.com
Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …

The evolution of lncRNA repertoires and expression patterns in tetrapods

A Necsulea, M Soumillon, M Warnefors, A Liechti… - Nature, 2014 - nature.com
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The
evolutionary history of lncRNAs can provide insights into their functionality, but the absence …

Long noncoding RNAs in organogenesis: making the difference

P Grote, BG Herrmann - Trends in Genetics, 2015 - cell.com
A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein
coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are …

Local regulation of gene expression by lncRNA promoters, transcription and splicing

JM Engreitz, JE Haines, EM Perez, G Munson, J Chen… - Nature, 2016 - nature.com
Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …

An atlas of human long non-coding RNAs with accurate 5′ ends

CC Hon, JA Ramilowski, J Harshbarger, N Bertin… - Nature, 2017 - nature.com
Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally
uncharacterized. Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we …

lncRNAs in development and differentiation: from sequence motifs to functional characterization

F Constanty, A Shkumatava - Development, 2021 - journals.biologists.com
The number of long noncoding RNAs (lncRNAs) with characterized developmental and
cellular functions continues to increase, but our understanding of the molecular mechanisms …

Significance of lncRNA abundance to function

I Grammatikakis, A Lal - Mammalian Genome, 2022 - Springer
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes.
Although the vast majority of lncRNAs are expressed at lower levels compared to …

Long noncoding RNAs in cell biology

MB Clark, JS Mattick - Seminars in cell & developmental biology, 2011 - Elsevier
Whole genome transcriptomic analyses have identified large numbers of dynamically
expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose …

Rapid turnover of long noncoding RNAs and the evolution of gene expression

C Kutter, S Watt, K Stefflova, MD Wilson… - PLoS …, 2012 - journals.plos.org
A large proportion of functional sequence within mammalian genomes falls outside protein-
coding exons and can be transcribed into long RNAs. However, the roles in mammalian …

Genomic and functional conservation of lncRNAs: lessons from flies

C Camilleri-Robles, R Amador, CC Klein, R Guigó… - Mammalian …, 2022 - Springer
Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to
the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically …