A dual-mode large-arrayed CMOS ISFET sensor for accurate and high-throughput pH sensing in biomedical diagnosis

X Huang, H Yu, X Liu, Y Jiang, M Yan… - IEEE Transactions on …, 2015 - ieeexplore.ieee.org
Goal: The existing ISFET-based DNA sequencing detects hydrogen ions released during the
polymerization of DNA strands on microbeads, which are scattered into microwell array …

A 64× 64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing

X Huang, F Wang, J Guo, M Yan, H Yu… - 2014 Symposium on …, 2014 - ieeexplore.ieee.org
A 64× 64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA
sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect …

Ultrafast large-scale chemical sensing with CMOS ISFETs: A level-crossing time-domain approach

Y Liu, TG Constandinou… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
The introduction of large-scale chemical sensing systems in CMOS which integrate millions
of ISFET sensors have allowed applications such as DNA sequencing and fine-pixel …

A scalable ISFET sensing and memory array with sensor auto-calibration for on-chip real-time DNA detection

N Moser, J Rodriguez-Manzano… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
This paper presents a novel CMOS-based system-onchip with a 78× 56 ion-sensitive field-
effect transistor array using in-pixel quantization and compensation of sensor nonidealities …

CMOS ion sensitive field effect transistors for highly sensitive detection of DNA hybridization

CF Chang, MSC Lu - IEEE Sensors Journal, 2020 - ieeexplore.ieee.org
CMOS (complementary metal oxide semiconductor) biosensors are promising to provide
label-free and highly sensitive detection with high throughput. Ion-sensitive field effect …

High-density 2-μm-pitch pH image sensor with high-speed operation up to 1933 fps

YN Lee, T Araki, Y Kimura, F Dasai… - IEEE transactions on …, 2019 - ieeexplore.ieee.org
Various biosensing platforms for real-time monitoring and mapping of chemical signals in
neural networks have been developed based on CMOS process technology. Despite their …

A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection

N Miscourides, LS Yu… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
This paper presents a large-scale CMOS chemicalsensing array operating in current mode
for real-time ion imaging and detection of DNA amplification. We show that the currentmode …

A robust ISFET pH-measuring front-end for chemical reaction monitoring

Y Hu, P Georgiou - IEEE Transactions on Biomedical Circuits …, 2014 - ieeexplore.ieee.org
This paper presents a robust, low-power and compact ion-sensitive field-effect transistor
(ISFET) sensing front-end for pH reaction monitoring using unmodified CMOS. Robustness …

[HTML][HTML] Real-time wash-free detection of unlabeled PNA-DNA hybridization using discrete FET sensor

M Kaisti, A Kerko, E Aarikka, P Saviranta, Z Boeva… - Scientific Reports, 2017 - nature.com
We demonstrate an electrochemical sensor for detection of unlabeled single-stranded DNA
using peptide nucleic acid (PNA) probes coupled to the field-effect transistor (FET) gate. The …

An optical and temperature assisted CMOS ISFET sensor array for robust E. coli detection

M Duan, X Zhong, X Zhao, OM El-Agnaf… - … Circuits and Systems, 2021 - ieeexplore.ieee.org
Both bacterial viability and concentration are significant metrics for bacterial detection.
Existing miniaturized and cost-effective single-mode sensor, pH or optical, can only be …