Inflammatory bowel diseases are characterised by inflammation that compromises the
integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has …

Claudins are a multigene transmembrane protein family comprising at least 27 members. In
gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of …

Highlights•Paracellular flux is regulated by dynamic tight junction protein
interactions.•Claudin interactions define small molecule flux across tight junction pores.• …

Claudin proteins comprise a recently described family of tight junction proteins that
differentially regulate paracellular permeability. Since other tight junction proteins show …

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of
macromolecules. The TJ is multi-protein complex that forms a selective permeable seal …

Background: Epithelial barrier function is impaired in Crohn's disease. Aim: To define the
underlying cellular mechanisms with special attention to tight junctions. Methods: Biopsy …

Epithelia form barriers that are essential to life. This is particularly true in the intestine, where
the epithelial barrier supports nutrient and water transport while preventing microbial …

The epithelium in inflamed intestinal segments of patients with Crohn's disease is
characterized by a reduction of tight junction strands, strand breaks, and alterations of tight …

Background and aims As integral membrane proteins, claudins form tight junctions together
with occludin. Several claudins were shown to be up-regulated in various cancer types. We …

Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal adenocarcinoma. The factors that result in IBD-associated carcinogenesis are not …