The Connection between the Toxicity of Anthracyclines and Their Ability to Modulate the P‐Glycoprotein‐Mediated Transport in A549, HepG2, and MCF‐7 Cells
A Rogalska, M Szwed, B Rychlik - The Scientific World Journal, 2014 - Wiley Online Library
Multidrug resistance (MDR) is a major obstacle to the successful chemotherapy of solid
tumors. We compared the resistance of the most popular solid tumors, breast …
tumors. We compared the resistance of the most popular solid tumors, breast …
Potentiation of anticancer drugs: Effects of pentoxifylline on neoplastic cells
M Barancik, V Bohacova, L Gibalova, J Sedlak… - International Journal of …, 2011 - mdpi.com
The drug efflux activity of P-glycoprotein (P-gp, a product of the mdr1 gene, ABCB1 member
of ABC transporter family) represents a mechanism by which tumor cells escape death …
of ABC transporter family) represents a mechanism by which tumor cells escape death …
Modulation of P-glycoprotein mediated drug accumulation in multidrug resistant CCRF VCR-1000 cells by chemosensitisers
R Boer, V Gekeler, WR Ulrich, P Zimmermann… - European Journal of …, 1996 - Elsevier
P-glycoprotein (PGP) mediated transport of cytostatic drugs out of resistant cancer cells is a
major cause of experimental and probably also of clinical multidrug resistance, which often …
major cause of experimental and probably also of clinical multidrug resistance, which often …
Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells
LJ Green, P Marder, CA Slapak - Biochemical pharmacology, 2001 - Elsevier
Resistance to chemotherapy by some human tumors may be due to overexpression of
membrane-associated transport proteins. The best characterized of these is the multidrug …
membrane-associated transport proteins. The best characterized of these is the multidrug …
Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp
G Kibria, H Hatakeyama, K Akiyama, K Hida… - Biological and …, 2014 - jstage.jst.go.jp
Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is
mediated by several factors. To design an effective therapy for the treatment of …
mediated by several factors. To design an effective therapy for the treatment of …
Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells
C Marbeuf-Gueye, HJ Broxterman, F Dubru… - Molecular …, 1998 - ASPET
The multidrug resistance protein (MRP) has been shown to mediate ATP-dependent efflux of
anticancer agents of diverse structure, such as daunorubicin (DNR), vincristine and …
anticancer agents of diverse structure, such as daunorubicin (DNR), vincristine and …
Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug
resistance (MDR). MDR is caused by the activity of various ATP binding cassette (ABC) …
resistance (MDR). MDR is caused by the activity of various ATP binding cassette (ABC) …
The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity
HS Mülder, H Dekker, HM Pinedo… - Biochemical pharmacology, 1995 - Elsevier
We have used a new methodology to measure the activity of P-glycoprotein (P-gp) in
multidrug-resistant (MDR) tumor cells. This activity leads to a lower cytosolic concentration …
multidrug-resistant (MDR) tumor cells. This activity leads to a lower cytosolic concentration …
The efflux of anthracyclines in multidrug-resistant cell lines
HM Coley, PR Twentyman, P Workman - Biochemical pharmacology, 1993 - Elsevier
In order to address the association of enhanced drug efflux with the multidrug-resistant
(MDR) phenotype, we have studied the cellular pharmacokinetics of anthracyclines in the P …
(MDR) phenotype, we have studied the cellular pharmacokinetics of anthracyclines in the P …
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1: MDR1 and Caco-2 cell lines
ICJ van der Sandt, MCM Blom-Roosemalen… - European journal of …, 2000 - Elsevier
The LLC-PK1: MDR1, LLC-PK1 and Caco-2 cell lines were used to investigate whether
rhodamine-123 or doxorubicin would be the preferred substrate to study P-glycoprotein (P …
rhodamine-123 or doxorubicin would be the preferred substrate to study P-glycoprotein (P …