Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting
lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial …

Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an
immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not …

The angiopoietin/Tie system plays a keyrole in remodeling and maturation of bloodvessels
as well as lymphatic vessels. The angiopoietinfamily includes four ligands (Ang-1, Ang-2 …

Angiopoietin (Ang) signaling plays a role in angiogenesis and remodeling of blood vessels
through the receptor tyrosine kinase Tie2, which is expressed on blood vessel endothelial …

Abstract Angiopoietin 1 (Ang1), a ligand for the receptor tyrosine kinase Tie2, regulates the
formation and stabilization of the blood vessel network during embryogenesis. In adults …

The maturation of the vascular system and the adjustment of blood vessel density in tissues
require the opposing processes of vessel growth and regression. A new study in this issue of …

Angiopoietin (Ang)-2, a ligand of the receptor tyrosine kinase Tie2, is known to be involved
in the regulation of embryonic lymphangiogenesis. However, the role of Ang-2 in postnatal …

VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While
Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on …

Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF
receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human …

The fine structure of lymphatic capillaries in the digestive organs of angiopoietin-2 (Ang2)
knockout mice was studied by using both immunohistochemistry and electron microscopy …