Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans.
Clinicians diagnose DR based on its characteristic vascular pathology, which is evident …

OBJECTIVE To determine 1) whether renal arginase activity or expression is increased in
diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN) …

Oxidative stress and inflammation in the vascular wall are essential mechanisms of
atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic …

As arginine can serve as precursor to a wide range of compounds, including nitric oxide,
creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest …