myogenic and muscle toxicity targets of environmental methylmercury exposure

LM Tam, MD Rand - Archives of Toxicology, 2024 - Springer
A number of environmental toxicants are noted for their activity that leads to declined motor
function. However, the role of muscle as a proximal toxicity target organ for environmental …

Developmental exposure to methylmercury and resultant muscle mercury accumulation and adult motor deficits in mice

MD Rand, K Conrad, E Marvin, K Harvey, D Henderson… - Neurotoxicology, 2020 - Elsevier
Developmental methylmercury (MeHg) exposure can have lasting consequences on neural
development and motor function across the lifespan. Recent evidence for MeHg targeting of …

Methylmercury myotoxicity targets formation of the myotendinous junction

AE Peppriell, JT Gunderson, D Vorojeikina, MD Rand - Toxicology, 2020 - Elsevier
Methylmercury (MeHg) is a ubiquitous environmental contaminant and developmental
toxicant known to cause a variety of persistent motor and cognitive deficits. While previous …

Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation

LM Prince, MD Rand - Toxicology, 2018 - Elsevier
Methylmercury (MeHg) is a ubiquitous environmental toxicant, best known for its selective
targeting of the developing nervous system. MeHg exposure has been shown to cause …

Methylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation

M Culbreth, MD Rand - Toxicology in Vitro, 2020 - Elsevier
Methylmercury (MeHg) is a pervasive environmental toxicant, with known detrimental effects
on neurodevelopment. Despite a longstanding paradigm of neurotoxicity, where motor …

[HTML][HTML] Genome-Wide Association Analysis of Tolerance to Methylmercury Toxicity in Drosophila Implicates Myogenic and Neuromuscular Developmental Pathways

SL Montgomery, D Vorojeikina, W Huang, TFC Mackay… - PloS one, 2014 - journals.plos.org
Methylmercury (MeHg) is a persistent environmental toxin present in seafood that can
compromise the developing nervous system in humans. The effects of MeHg toxicity varies …

The effect of methylmercury on skeletal muscle in the rat: a histopathological study

F Usuki, A Yasutake, M Matsumoto, F Umehara… - Toxicology letters, 1998 - Elsevier
Methylmercury (MeHg)-induced neurotoxicity includes skeletal muscle symptoms (extremity
weakness and wasting, muscle cramp) in addition to ataxia and disturbances of sensory and …

Methylmercury impairs motor function in early development and induces oxidative stress in cerebellar granule cells

E Patel, M Reynolds - Toxicology Letters, 2013 - Elsevier
Environmental toxicants such as methylmercury play a critical role in the pathogenesis of
many neurodevelopmental disorders. Environmental exposure to methylmercury frequently …

Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57/B6 mice

KS Montgomery, J Mackey, K Thuett, S Ginestra… - Behavioural Brain …, 2008 - Elsevier
Methylmercury (MeHg) has cytotoxic effects on animals and humans, and a major target
organ for MeHg is the central nervous system (CNS). It is well known that the developing …

Prenatal exposure to methylmercury alters locomotor activity of male but not female rats

AD Rossi, E Ahlbom, SO Ögren, P Nicotera… - Experimental Brain …, 1997 - Springer
In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of
methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats …