Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance

K Cassady, H Gagnon, P Lalwani, M Simmonite… - Neuroimage, 2019 - Elsevier
Aging is typically associated with declines in sensorimotor performance. Previous studies
have linked some age-related behavioral declines to reductions in network segregation. For …

[HTML][HTML] Network segregation varies with neural distinctiveness in sensorimotor cortex

K Cassady, H Gagnon, E Freiburger, P Lalwani… - NeuroImage, 2020 - Elsevier
Normal aging is associated with declines in sensorimotor function. Previous studies have
linked age-related behavioral declines to decreases in neural differentiation (ie …

Decreased segregation of brain systems across the healthy adult lifespan

MY Chan, DC Park, NK Savalia… - Proceedings of the …, 2014 - National Acad Sciences
Healthy aging has been associated with decreased specialization in brain function. This
characterization has focused largely on describing age-accompanied differences in …

[HTML][HTML] Aging relates to a disproportionately weaker functional architecture of brain networks during rest and task states

C Hughes, J Faskowitz, BS Cassidy, O Sporns… - NeuroImage, 2020 - Elsevier
Functional connectivity–the co-activation of brain regions–forms the basis of the brain's
functional architecture. Often measured during resting-state (ie, in a task-free setting) …

Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults

R Seidler, B Erdeniz, V Koppelmans, S Hirsiger… - Neuroimage, 2015 - Elsevier
Aging is associated with impaired motor performance across a range of tasks. Both primary
neural representations of movement and potential compensatory cognitive mechanisms …

Age-related reorganizational changes in modularity and functional connectivity of human brain networks

J Song, RM Birn, M Boly, TB Meier, VA Nair… - Brain …, 2014 - liebertpub.com
The human brain undergoes both morphological and functional modifications across the
human lifespan. It is important to understand the aspects of brain reorganization that are …

[HTML][HTML] When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging

R Pedersen, L Geerligs, M Andersson, T Gorbach… - Neuroimage, 2021 - Elsevier
Healthy aging is accompanied by progressive decline in cognitive performance and
concomitant changes in brain structure and functional architecture. Age-accompanied …

Brain network segregation and glucose energy utilization: relevance for age-related differences in cognitive function

P Manza, CE Wiers, E Shokri-Kojori, D Kroll… - Cerebral …, 2020 - academic.oup.com
The human brain is organized into segregated networks with strong within-network
connections and relatively weaker between-network connections. This “small-world” …

A brain-wide study of age-related changes in functional connectivity

L Geerligs, RJ Renken, E Saliasi, NM Maurits… - Cerebral …, 2015 - academic.oup.com
Aging affects functional connectivity between brain areas, however, a complete picture of
how aging affects integration of information within and between functional networks is …

Longitudinal changes in the cerebral cortex functional organization of healthy elderly

JSX Chong, KK Ng, J Tandi, C Wang… - Journal of …, 2019 - Soc Neuroscience
Healthy aging is accompanied by disruptions in the functional modular organization of the
human brain. Cross-sectional studies have shown age-related reductions in the functional …