Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …

Of all the proposed causes of ageing, DNA damage remains a leading, though still debated
theory. Unlike most other types of age-related cellular damage, which can hypothetically be …

Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

The accumulation of stochastic DNA damage throughout an organism's lifespan is thought to
contribute to ageing. Conversely, ageing seems to be phenotypically reproducible and …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Aging represents the progressive functional decline and increased mortality risk common to
nearly all metazoans. Recent findings experimentally link DNA damage and organismal …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …