Orthopedic infections due to biofilm formation in biomaterial-based implants have become
challenging in bone tissue engineering. In the present study, in vitro antibacterial analysis of …

Treatment of infected bone defects still remains a formidable clinical challenge, the design of
bone implants with the controlled release of antibiotics is now regarded as a powerful …

An effective local drug delivery system remains an urgently needed product for the treatment
of chronic osteomyelitis in the clinic. In this study, we developed an antibacterial …

Poly (methyl methacrylate)-based bone cements are functionalized with mesoporous silica
nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to …

The ability of bacteria to form biofilms hinders any conventional treatment for chronic
infections and has serious socio-economic implications. For this purpose, a nanocarrier …

Abstract Lev/MSNs/n-HA/PU has been proved to be a novel scaffold material to treat bone
defect caused by chronic osteomyelitis. We have previously identified that this material can …

Since conventional antibiotics are almost ineffective on methicillin-resistant Staphylococcus
aureus (MRSA) strains, designing their antibacterial alternatives is necessary. Besides, the …

This manuscript reports an effective new alternative for the management of bone infection by
the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus …

Abstract Treatment of septic arthritis has become a major challenge due to the increasing
frequency of antibiotic resistance developed by Staphylococcus aureus. Combination drug …

Antibiotic resistance has become a global threat to health due to abuse of antibiotics. Lots of
existing antibiotics have lost their effect on drug resistant bacteria. Moreover, the discovery …