Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …
Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve …
Identifying molecular mechanisms of exhausted CD8 T cells (Tex) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in …
M Shakiba, P Zumbo, G Espinosa-Carrasco… - Journal of Experimental …, 2021 - rupress.org
T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor …
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based …
DG Gennert, RC Lynn, JM Granja… - Proceedings of the …, 2021 - National Acad Sciences
Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting …
Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …
A Baessler, DAA Vignali - Annual Review of Immunology, 2024 - annualreviews.org
T cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and …
P Zhou, H Shi, H Huang, X Sun, S Yuan, NM Chapman… - Nature, 2023 - nature.com
CD8+ cytotoxic T cells (CTLs) orchestrate antitumour immunity and exhibit inherent heterogeneity,, with precursor exhausted T (Tpex) cells but not terminally exhausted T (Tex) …