SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells

K Meyer, T Patra, Vijayamahantesh, R Ray - Journal of virology, 2021 - Am Soc Microbiol
Increased mortality in COVID-19 cases is often associated with microvascular complications.
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

[HTML][HTML] SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

YJ Suzuki, SI Nikolaienko, VA Dibrova, YV Dibrova… - Vascular …, 2021 - Elsevier
Currently, the world is suffering from the pandemic of coronavirus disease 2019 (COVID-19),
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses …

Endothelial cell activation by SARS-CoV-2 spike S1 protein: a crosstalk between endothelium and innate immune cells

BM Rotoli, A Barilli, R Visigalli, F Ferrari, V Dall'Asta - Biomedicines, 2021 - mdpi.com
Background. Emerging evidences suggest that in severe COVID-19, multi-organ failure is
associated with a hyperinflammatory state (the so-called “cytokine storm”) in combination …

[HTML][HTML] The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human …

RMLC Biancatelli, PA Solopov… - … of Physiology-Lung …, 2021 - journals.physiology.org
Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of
COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface …

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication

AC Montezano, LL Camargo, S Mary, KB Neves… - Scientific Reports, 2023 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is a respiratory disease associated with
inflammation and endotheliitis. Mechanisms underling inflammatory processes are unclear …

Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction

R Urata, K Ikeda, E Yamazaki, D Ueno, A Katayama… - Scientific Reports, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19), caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains to spread worldwide. COVID-19 …

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …

[HTML][HTML] SARS-CoV-2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity

S Raghavan, DB Kenchappa, MD Leo - Frontiers in cardiovascular …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin
converting enzyme 2 (ACE-2) receptor present on the cell surface to enter cells. ACE-2 is …

[HTML][HTML] HSP90 inhibitors modulate SARS-CoV-2 spike protein subunit 1-induced human pulmonary microvascular endothelial activation and barrier dysfunction

RML Colunga Biancatelli, PA Solopov… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 5
million deaths worldwide. Multiple reports indicate that the endothelium is involved during …

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

T Patra, K Meyer, L Geerling, TS Isbell, DF Hoft… - PLoS …, 2020 - journals.plos.org
Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …