WNT as a driver and dependency in cancer

MJ Parsons, T Tammela, LE Dow - Cancer discovery, 2021 - AACR
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

[HTML][HTML] Wnt pathway: an integral hub for developmental and oncogenic signaling networks

M Sharma, K Pruitt - International journal of molecular sciences, 2020 - mdpi.com
The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial
development processes and maintenance of tissue homeostasis by coordinating cell …

[HTML][HTML] Wnt signaling in cancer

T Zhan, N Rindtorff, M Boutros - Oncogene, 2017 - nature.com
Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

[HTML][HTML] A review of the role of Wnt in cancer immunomodulation

WN Goldsberry, A Londoño, TD Randall, LA Norian… - Cancers, 2019 - mdpi.com
Alterations in the Wnt signaling pathway are associated with the advancement of cancers;
however, the exact mechanisms responsible remain largely unknown. It has recently been …

Wnts and the hallmarks of cancer

Z Zhong, J Yu, DM Virshup, B Madan - Cancer and Metastasis Reviews, 2020 - Springer
Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

The Wnt signaling pathway: a potential therapeutic target against cancer

N Ghosh, U Hossain, A Mandal… - Annals of the New York …, 2019 - Wiley Online Library
The role of the evolutionarily conserved Wnt signaling pathway is well documented in
several cellular processes, such as cell proliferation, differentiation, cell motility, and …

The Wnt signaling pathway in cancer

Y Duchartre, YM Kim, M Kahn - Critical reviews in oncology/hematology, 2016 - Elsevier
The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

[HTML][HTML] WNT signaling in disease

LF Ng, P Kaur, N Bunnag, J Suresh, ICH Sung, QH Tan… - Cells, 2019 - mdpi.com
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Wnt signaling pathway in cancer immunotherapy

Y Zhou, J Xu, H Luo, X Meng, M Chen, D Zhu - Cancer letters, 2022 - Elsevier
Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …

[HTML][HTML] Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

YS Jung, JI Park - Experimental & Molecular Medicine, 2020 - nature.com
Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …