Studies using diverse methods have documented frontostriatal and limbic dysfunction
occurring in late-life depression. Although such impairments may result from aging-induced …

BACKGROUND: Executive dysfunction is common in geriatric depression and persists after
improvement of depressive symptoms. This study examined the relationship of executive …

Late life depression principally affects individuals with other medical and psychosocial
problems, including cognitive dysfunction, disability, medical illnesses, and social isolation …

Objective: Deep white matter hyperintense lesions are associated with advanced age and
late-life depression. The authors examined where age-related cerebral lesions occurred in …

Although the pathophysiology of depression is not fully understood in either primary
depression (ie, no known neuropathology related to depression) or secondary depression …

Executive function, known to be impaired during late-life depression, is dependent on
frontostriatal pathways. Memory is also frequently observed to be impaired among late-life …

This study investigated the relationship of executive impairment and heart disease burden to
remission of major depression among elderly patients. A total of 112 elderly subjects …

Late-onset depression has been conceptualized as a neurologic disease. This view has
been supported by studies suggesting that late-onset depression is associated with …

Background This study investigated the relationship of executive and memory impairment to
relapse, recurrence, and course of residual depressive symptoms and signs after remission …

Recent accounts of major depression have tended to focus on dysfunction of frontothalamic-
striatal reentrant circuits as a possible source of the disorder. Evidence of frontostriatal …