Over 20 years of neuroimaging experiments into aberrant task-based brain activity in
unipolar depression have failed to reliably delineate a convergent set of anatomical regions …

Depression is a multifactorial disorder with clinically heterogeneous features involving
disturbances of mood and cognitive function. Noninvasive neuroimaging studies have …

Biomarkers have transformed modern medicine but remain largely elusive in psychiatry,
partly because there is a weak correspondence between diagnostic labels and their …

Multiple sclerosis (MS), a demyelinating disease that causes focal white matter lesions, is
commonly associated with depression. However, it remains unclear whether depression risk …

Background Despite efforts to improve targeting accuracy of the dorsolateral prefrontal
cortex (DLPFC) as a repetitive transcranial magnetic stimulation (rTMS) target for Major …

Background Disorders of mood and cognition are prevalent, disabling, and notoriously
difficult to treat. Fueling this challenge in treatment is a significant gap in our understanding …

Resting-state functional magnetic resonance imaging provides a noninvasive method to
rapidly map large-scale brain networks affected in depression and other psychiatric …

Background There is well-known heterogeneity in affective mechanisms in depression that
may extend to positive affect. We used data-driven parsing of neural connectivity to reveal …

Background Depression is a heterogeneous mental illness. Neurostimulation treatments, by
targeting specific nodes within the brain's emotion-regulation network, may be useful both as …

There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …