Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and
their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic …

We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis.
Bmi1 is detected at higher levels in androgen-independent PC3 and DU145 than in …

BMI1 plays critical roles in maintaining the self-renewal of hematopoietic, neural, intestinal
stem cells, and cancer stem cells (CSCs) for a variety of cancer types. BMI1 promotes cell …

B cell-specific moloney murine leukemia virus integration site 1 (BMI1) is a transcriptional
repressor of polycomb repressive complex 1, which is involved in the proliferation …

Background BMI-1 is a member of the polycomb group of genes (PcGs), and it has been
implicated in the development and progression of several malignancies, but its role in …

BMI1, a polycomb group (PcG) protein, plays a critical role in epigenetic regulation of cell
differentiation and proliferation, and cancer stem cell self-renewal. BMI1 is upregulated in …

It is well documented that B cell-specific Moloney murine leukemia virus integration site 1
(Bmi-1), widely overexpressed in the vast majority of malignancies, plays an essential role in …

Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by
regulating chromatin structure and is indispensable for self-renewal of both normal and …

Epigenetic dysregulation is involved in the initiation and progression of many epithelial
cancers. BMI1, a component of the polycomb protein family, plays a key role in these …

B‐cell‐specific Moloney murine leukemia virus insertion site 1 (BMI1) is a member of the
polycomb group of transcriptional repressors. Until now, its expression and functional …