Surface immobilization of anti-VEGF peptide on SPIONs for antiangiogenic and targeted delivery of paclitaxel in non-small-cell lung carcinoma

LM Ngema, SA Adeyemi, T Marimuthu… - ACS Applied Bio …, 2023 - ACS Publications
A design has been established for the surface decoration of superparamagnetic iron oxide
nanoparticles (SPIONs) with anti-vascular endothelial growth factor peptide, HRH, to …

Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor …

LM Ngema, SA Adeyemi, T Marimuthu, PN Ubanako… - ACS …, 2023 - ACS Publications
The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs
presents a viable approach for effective management of nonsmall-cell lung carcinoma …

Synthesis of novel conjugated linoleic acid (CLA)-coated superparamagnetic iron oxide nanoparticles (SPIONs) for the delivery of paclitaxel with enhanced in vitro anti …

LM Ngema, SA Adeyemi, T Marimuthu, P Ubanako… - Pharmaceutics, 2022 - mdpi.com
The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a
nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective delivery …

Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy

M Mahmoudi, S Sant, B Wang, S Laurent… - Advanced drug delivery …, 2011 - Elsevier
At present, nanoparticles are used for various biomedical applications where they facilitate
laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the …

Targeted anticancer drug delivery via surface engineered iron oxide nanoparticles: A recent update

A Parmanik, A Bose - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Cancer treatment is a challenging task due to the complexity and variation of the disease,
late diagnosis, and severe side effects of the antineoplastic agents. Targeted drug delivery …

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

A Niescioruk, D Nieciecka, AK Puszko… - Journal of Nanoparticle …, 2017 - Springer
Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as
targeted drug delivery vehicles, because they can be guided to their target with the help of …

Synthesis, characterization and theranostic evaluation of Indium-111 labeled multifunctional superparamagnetic iron oxide nanoparticles

H Zolata, FA Davani, H Afarideh - Nuclear medicine and biology, 2015 - Elsevier
Abstract Indium-111 labeled, Trastuzumab-Doxorubicin Conjugated, and APTES-PEG
coated magnetic nanoparticles were designed for tumor targeting, drug delivery, controlled …

Manipulation and elimination of circulating tumor cells using multi-responsive nanosheet for malignant tumor therapy

T Liu, B Cai, P Yuan, L Wang, R Tian, T Dai… - Biomaterials …, 2023 - pubs.rsc.org
Tumor recurrence caused by metastasis is a major cause of death for patients. Thus, a
strategy to manipulate the circulating tumor cells (CTCs, initiators of tumor metastasis) and …

Utilization of superparamagnetic iron oxide nanoparticles (SPIONs) as a vector for drug delivery

E Otieno, Y Huang, N Li, T Li, M Wang, X Qiu… - Applied …, 2023 - Springer
Many available chemotherapeutic methods are faced with multiple challenges that range
from therapeutic failure to detrimental adverse or toxicity effects. Most of the drugs have low …

Optimization, characterization and in vivo evaluation of paclitaxel-loaded folate-conjugated superparamagnetic iron oxide nanoparticles

G Gui, Z Fan, Y Ning, C Yuan, B Zhang… - International Journal of …, 2021 - Taylor & Francis
Background Paclitaxel (PTX) has interesting anticancer activity. However, it is insoluble in
water, which seriously hinders its use in clinical. Superparamagnetic iron oxide …