Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …

Evidence suggests a unique association between bone aging and neurodegenerative/
cerebrovascular disorders. However, the mechanisms underlying bone‐brain interplay …

Brain calcifications are commonly detected in aged individuals and accompany numerous
brain diseases, but their functional importance is not understood. In cases of primary familial …

Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by
progressive pericapillary calcifications, has recently been linked to heterozygous mutations …

Evidence links osteoporosis and cardiovascular disease but the cellular and molecular
mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor …

Vascular calcification, a pathologic response to defective calcium and phosphate
homeostasis, is strongly associated with cardiovascular mortality and morbidity. In this study …

Cardiovascular disease (CVD) and osteoporosis often occur together, suggesting an
association between CVD and bone loss. Similarly, the correlation of bone loss …

Objective—Vascular calcification is an important risk factor for cardiovascular diseases.
Here, we investigated a role of dedifferentiated vascular smooth muscle cells (VSMCs) in the …

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis
imperfecta. However, the mechanisms controlling bone quality are not well understood …

Arterial calcification is an important hallmark of cardiovascular disease and shares many
similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an …