Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system

G Tejeda, AJ Ciciriello, CM Dumont - Cells Tissues Organs, 2023 - karger.com
Stem cell therapies have the potential to not only repair, but to regenerate tissue of the
central nervous system (CNS). Recent studies demonstrate that transplanted stem cells can …

Creating permissive microenvironments for stem cell transplantation into the central nervous system

H Kim, MJ Cooke, MS Shoichet - Trends in biotechnology, 2012 - cell.com
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical
need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are …

Harnessing stem cells and biomaterials to promote neural repair

KF Bruggeman, N Moriarty, E Dowd… - British journal of …, 2019 - Wiley Online Library
With the limited capacity for self‐repair in the adult CNS, efforts to stimulate quiescent stem
cell populations within discrete brain regions, as well as harness the potential of stem cell …

Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma

I Kulbatski, AJ Mothe, H Nomura… - Current drug targets, 2005 - ingentaconnect.com
Neural stem/progenitor cells capable of generating new neurons and glia, reside in specific
areas of the adult mammalian central nervous system (CNS), including the ependymal …

Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system

MJ Cooke, K Vulic, MS Shoichet - Soft Matter, 2010 - pubs.rsc.org
Following injury to the central nervous system (CNS) there is a cascade of events that leads
to cell death, tissue loss and consequently functional deficit. In response to injury, the CNS …

Biomaterials for enhancing CNS repair

TC Lim, M Spector - Translational stroke research, 2017 - Springer
The health of the central nervous system (CNS) does not only rely on the state of the neural
cells but also on how various extracellular components organize cellular behaviors into …

Matrices, scaffolds & carriers for cell delivery in nerve regeneration

ZZ Wang, SE Sakiyama-Elbert - Experimental neurology, 2019 - Elsevier
Nerve injuries can be life-long debilitating traumas that severely impact patients' quality of
life. While many acellular neural scaffolds have been developed to aid the process of nerve …

[HTML][HTML] The potential of biomaterials for central nervous system cellular repair

S Jarrin, S Cabre, E Dowd - Neurochemistry International, 2021 - Elsevier
The central nervous system (CNS) can be injured or damaged through a variety of insults
including traumatic injury, stroke, and neurodegenerative or demyelinating diseases …

Improvements in biomaterial matrices for neural precursor cell transplantation

NB Skop, F Calderon, CH Cho, CD Gandhi… - Molecular and cellular …, 2014 - Springer
Progress is being made in developing neuroprotective strategies for traumatic brain injuries;
however, there will never be a therapy that will fully preserve neurons that are injured from …