Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

Drug transporters are well-recognized determinants of drug disposition and effects/toxicity.
These are divided into solute carrier (SLC) family and ATP-binding cassette (ABC) family …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

Drug–drug interactions are a serious clinical issue. An important mechanism underlying
drug–drug interactions is induction or inhibition of drug transporters that mediate the cellular …

Transporters comprise the largest family of membrane proteins in human organism,
including members of solute carrier transporter and ATP-binding cassette transporter …

Since 1994, researchers have isolated various genes encoding transporter proteins
involved in drug uptake into and eŒux from tissues that play key roles in the absorption …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

Transporters are membrane‐bound proteins that control the access of endogenous and
xenobiotics (drugs) to various sites in the human body. They influence drug …

Recently, increased interest in drug transporters and research in this area has revealed that
drug transporters play an important role in modulating drug absorption, distribution, and …

Oral bioavailability (F) is determined as fraction of the drug dose absorbed through the
gastrointestinal membranes (Fa), the unmetabolized fraction of the absorbed dose that …