The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

DNA damage is a form of cell stress and injury that has been implicated in the pathogenesis
of many neurologic disorders, including amyotrophic lateral sclerosis, Alzheimer disease …

Defective responses to DNA single-or double-strand breaks can result in neurological
disease, underscoring the critical importance of DNA repair for neural homeostasis. Human …

Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …

Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

The DNA damage response is a key factor in the maintenance of genome stability. As such,
it is a central axis in sustaining cellular homeostasis in a variety of contexts: development …

Damage to DNA is generally considered to be a harmful process associated with aging and
aging-related disorders such as neurodegenerative diseases that involve the selective …

The ability to respond to genotoxic stress is a prerequisite for the successful development of
the nervous system. Mutations in various DNA repair factors can lead to human diseases …

Many human pathological conditions with genetic defects in DNA damage responses are
also characterized by neurological deficits. These neurological deficits can manifest …

Multiple DNA repair pathways maintain genome stability and ensure that DNA remains
essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is …