The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …

Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The
prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors. Recent …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …

The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects
of pain. There is extensive evidence that chronic pain produces functional changes within …

Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain
represents a complex disorder with anxio-depressive symptoms and cognitive deficits …

Frontal lobe activity during pain is generally linked to attentional processing. We addressed
the question of whether 'bottom‐up'processing and 'top‐down'modulation of nociceptive …

Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous
system. Depression and cognitive decline are often coupled to chronic pain, suggesting the …

The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous
region and a key node of several brain networks, implicated in cognitive, affective, and …